PoplarV1, Main, Exploration, bibRecord, 002627

Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.

Identifieur interne : 002627 ( Main/Exploration ); précédent : 002626; suivant : 002628

Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.

Auteurs : Guangshu Zhai [États-Unis] ; Hans-Joachim Lehmler ; Jerald L. Schnoor

Source :

Environmental science & technology [ 1520-5851 ] ; 2013.

RBID : pubmed:23320482

Descripteurs français

KwdFr :
- Acides gras insaturés (pharmacologie), Antienzymes (pharmacologie), Cytochrome P-450 enzyme system (métabolisme), Dérivés du biphényle (métabolisme), Inhibiteurs des enzymes du cytochrome P-450 (MeSH), Polluants environnementaux (métabolisme), Populus (effets des médicaments et des substances chimiques), Populus (métabolisme), Triazoles (pharmacologie).
MESH :
- effets des médicaments et des substances chimiques : Populus.
- métabolisme : Cytochrome P-450 enzyme system, Dérivés du biphényle, Polluants environnementaux, Populus.
- pharmacologie : Acides gras insaturés, Antienzymes, Triazoles.
- Inhibiteurs des enzymes du cytochrome P-450.

English descriptors

KwdEn :
- Biphenyl Compounds (metabolism), Cytochrome P-450 Enzyme Inhibitors (MeSH), Cytochrome P-450 Enzyme System (metabolism), Environmental Pollutants (metabolism), Enzyme Inhibitors (pharmacology), Fatty Acids, Unsaturated (pharmacology), Populus (drug effects), Populus (metabolism), Triazoles (pharmacology).
MESH :
- chemical , metabolism : Biphenyl Compounds, Cytochrome P-450 Enzyme System, Environmental Pollutants.
- chemical , pharmacology : Enzyme Inhibitors, Fatty Acids, Unsaturated, Triazoles.
- chemical : Cytochrome P-450 Enzyme Inhibitors.
- drug effects : Populus.
- metabolism : Populus.

Abstract

Cytochromes P450 (CYPs) are potential enzymes responsible for hydroxylation of many xenobiotics and endogenous chemicals in living organisms. It has been found that 4-monochlorobiphenyl (PCB3), mainly an airborne pollutant, can be metabolized to hydroxylated transformation products (OH-PCB3s) in whole poplars. However, the enzymes involved in the hydroxylation of PCB3 in whole poplars have not been identified. Therefore, two CYP suicide inhibitors, 1-aminobenzotriazole (ABT) and 17-octadecynoic acid (ODYA), were selected to probe the hydroxylation reaction of PCB3 in whole poplars in this work. Poplars (Populus deltoides × nigra, DN34) were exposed to PCB3 with or without inhibitor for 11 days. Results showed both ABT and ODYA can decrease the concentrations and yields of five OH-PCB3s in different poplar parts via the inhibition of CYPs. Furthermore, both ABT and ODYA demonstrated a dose-dependent relationship to the formation of OH-PCB3s in whole poplars. The higher the inhibitor concentrations, the lower the total yields of OH-PCB3s. For ABT spiked-additions, the total mass yield of five OH-PCB3s was inhibited by a factor of 1.6 times at an ABT concentration of 2.5 mg L(-1), 4.0 times at 12.5 mg L(-1), and 7.0 times at 25 mg L(-1). For the inhibitor ODYA, the total mass of five OH-PCB3s was reduced by 2.1 times compared to the control at an ODYA concentration of 2.5 mg L(-1). All results pointed to the conclusion that CYP enzymes were the agents which metabolized PCB3 to OH-PCB3s in whole poplars because suicide CYP inhibitors ABT and ODYA both led to sharp decreases of OH-PCB3s formation in whole poplars. A dose-response curve for each of the suicide inhibitors was developed.

DOI: 10.1021/es304298m
PubMed: 23320482
PubMed Central: PMC3652898

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 002730
to stream Main, to step Curation: 002730

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.</title>
<author><name sortKey="Zhai, Guangshu" sort="Zhai, Guangshu" uniqKey="Zhai G" first="Guangshu" last="Zhai">Guangshu Zhai</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Civil and Environmental Engineering and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242, United States. zhai-guangshu@uiowa.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Civil and Environmental Engineering and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242</wicri:regionArea>
<orgName type="university">Université de l'Iowa</orgName>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lehmler, Hans Joachim" sort="Lehmler, Hans Joachim" uniqKey="Lehmler H" first="Hans-Joachim" last="Lehmler">Hans-Joachim Lehmler</name>
</author>
<author><name sortKey="Schnoor, Jerald L" sort="Schnoor, Jerald L" uniqKey="Schnoor J" first="Jerald L" last="Schnoor">Jerald L. Schnoor</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23320482</idno>
<idno type="pmid">23320482</idno>
<idno type="doi">10.1021/es304298m</idno>
<idno type="pmc">PMC3652898</idno>
<idno type="wicri:Area/Main/Corpus">002730</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">002730</idno>
<idno type="wicri:Area/Main/Curation">002730</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">002730</idno>
<idno type="wicri:Area/Main/Exploration">002730</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.</title>
<author><name sortKey="Zhai, Guangshu" sort="Zhai, Guangshu" uniqKey="Zhai G" first="Guangshu" last="Zhai">Guangshu Zhai</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Civil and Environmental Engineering and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242, United States. zhai-guangshu@uiowa.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Civil and Environmental Engineering and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242</wicri:regionArea>
<orgName type="university">Université de l'Iowa</orgName>
<placeName><settlement type="city">Iowa City</settlement>
<region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lehmler, Hans Joachim" sort="Lehmler, Hans Joachim" uniqKey="Lehmler H" first="Hans-Joachim" last="Lehmler">Hans-Joachim Lehmler</name>
</author>
<author><name sortKey="Schnoor, Jerald L" sort="Schnoor, Jerald L" uniqKey="Schnoor J" first="Jerald L" last="Schnoor">Jerald L. Schnoor</name>
</author>
</analytic>
<series><title level="j">Environmental science & technology</title>
<idno type="eISSN">1520-5851</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biphenyl Compounds (metabolism)</term>
<term>Cytochrome P-450 Enzyme Inhibitors (MeSH)</term>
<term>Cytochrome P-450 Enzyme System (metabolism)</term>
<term>Environmental Pollutants (metabolism)</term>
<term>Enzyme Inhibitors (pharmacology)</term>
<term>Fatty Acids, Unsaturated (pharmacology)</term>
<term>Populus (drug effects)</term>
<term>Populus (metabolism)</term>
<term>Triazoles (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras insaturés (pharmacologie)</term>
<term>Antienzymes (pharmacologie)</term>
<term>Cytochrome P-450 enzyme system (métabolisme)</term>
<term>Dérivés du biphényle (métabolisme)</term>
<term>Inhibiteurs des enzymes du cytochrome P-450 (MeSH)</term>
<term>Polluants environnementaux (métabolisme)</term>
<term>Populus (effets des médicaments et des substances chimiques)</term>
<term>Populus (métabolisme)</term>
<term>Triazoles (pharmacologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biphenyl Compounds</term>
<term>Cytochrome P-450 Enzyme System</term>
<term>Environmental Pollutants</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Enzyme Inhibitors</term>
<term>Fatty Acids, Unsaturated</term>
<term>Triazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Cytochrome P-450 Enzyme Inhibitors</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytochrome P-450 enzyme system</term>
<term>Dérivés du biphényle</term>
<term>Polluants environnementaux</term>
<term>Populus</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Acides gras insaturés</term>
<term>Antienzymes</term>
<term>Triazoles</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Inhibiteurs des enzymes du cytochrome P-450</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Cytochromes P450 (CYPs) are potential enzymes responsible for hydroxylation of many xenobiotics and endogenous chemicals in living organisms. It has been found that 4-monochlorobiphenyl (PCB3), mainly an airborne pollutant, can be metabolized to hydroxylated transformation products (OH-PCB3s) in whole poplars. However, the enzymes involved in the hydroxylation of PCB3 in whole poplars have not been identified. Therefore, two CYP suicide inhibitors, 1-aminobenzotriazole (ABT) and 17-octadecynoic acid (ODYA), were selected to probe the hydroxylation reaction of PCB3 in whole poplars in this work. Poplars (Populus deltoides × nigra, DN34) were exposed to PCB3 with or without inhibitor for 11 days. Results showed both ABT and ODYA can decrease the concentrations and yields of five OH-PCB3s in different poplar parts via the inhibition of CYPs. Furthermore, both ABT and ODYA demonstrated a dose-dependent relationship to the formation of OH-PCB3s in whole poplars. The higher the inhibitor concentrations, the lower the total yields of OH-PCB3s. For ABT spiked-additions, the total mass yield of five OH-PCB3s was inhibited by a factor of 1.6 times at an ABT concentration of 2.5 mg L(-1), 4.0 times at 12.5 mg L(-1), and 7.0 times at 25 mg L(-1). For the inhibitor ODYA, the total mass of five OH-PCB3s was reduced by 2.1 times compared to the control at an ODYA concentration of 2.5 mg L(-1). All results pointed to the conclusion that CYP enzymes were the agents which metabolized PCB3 to OH-PCB3s in whole poplars because suicide CYP inhibitors ABT and ODYA both led to sharp decreases of OH-PCB3s formation in whole poplars. A dose-response curve for each of the suicide inhibitors was developed. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23320482</PMID>
<DateCompleted><Year>2014</Year>
<Month>04</Month>
<Day>21</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1520-5851</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>47</Volume>
<Issue>13</Issue>
<PubDate><Year>2013</Year>
<Month>Jul</Month>
<Day>02</Day>
</PubDate>
</JournalIssue>
<Title>Environmental science & technology</Title>
<ISOAbbreviation>Environ Sci Technol</ISOAbbreviation>
</Journal>
<ArticleTitle>Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.</ArticleTitle>
<Pagination><MedlinePgn>6829-35</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1021/es304298m</ELocationID>
<Abstract><AbstractText>Cytochromes P450 (CYPs) are potential enzymes responsible for hydroxylation of many xenobiotics and endogenous chemicals in living organisms. It has been found that 4-monochlorobiphenyl (PCB3), mainly an airborne pollutant, can be metabolized to hydroxylated transformation products (OH-PCB3s) in whole poplars. However, the enzymes involved in the hydroxylation of PCB3 in whole poplars have not been identified. Therefore, two CYP suicide inhibitors, 1-aminobenzotriazole (ABT) and 17-octadecynoic acid (ODYA), were selected to probe the hydroxylation reaction of PCB3 in whole poplars in this work. Poplars (Populus deltoides × nigra, DN34) were exposed to PCB3 with or without inhibitor for 11 days. Results showed both ABT and ODYA can decrease the concentrations and yields of five OH-PCB3s in different poplar parts via the inhibition of CYPs. Furthermore, both ABT and ODYA demonstrated a dose-dependent relationship to the formation of OH-PCB3s in whole poplars. The higher the inhibitor concentrations, the lower the total yields of OH-PCB3s. For ABT spiked-additions, the total mass yield of five OH-PCB3s was inhibited by a factor of 1.6 times at an ABT concentration of 2.5 mg L(-1), 4.0 times at 12.5 mg L(-1), and 7.0 times at 25 mg L(-1). For the inhibitor ODYA, the total mass of five OH-PCB3s was reduced by 2.1 times compared to the control at an ODYA concentration of 2.5 mg L(-1). All results pointed to the conclusion that CYP enzymes were the agents which metabolized PCB3 to OH-PCB3s in whole poplars because suicide CYP inhibitors ABT and ODYA both led to sharp decreases of OH-PCB3s formation in whole poplars. A dose-response curve for each of the suicide inhibitors was developed. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhai</LastName>
<ForeName>Guangshu</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Civil and Environmental Engineering and IIHR Hydroscience and Engineering, The University of Iowa, Iowa City, Iowa 52242, United States. zhai-guangshu@uiowa.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lehmler</LastName>
<ForeName>Hans-Joachim</ForeName>
<Initials>HJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Schnoor</LastName>
<ForeName>Jerald L</ForeName>
<Initials>JL</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 ES005605</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P42 ES013661</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P42ES013661</GrantID>
<Acronym>ES</Acronym>
<Agency>NIEHS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>01</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Environ Sci Technol</MedlineTA>
<NlmUniqueID>0213155</NlmUniqueID>
<ISSNLinking>0013-936X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001713">Biphenyl Compounds</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D065607">Cytochrome P-450 Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004785">Environmental Pollutants</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004791">Enzyme Inhibitors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D005231">Fatty Acids, Unsaturated</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014230">Triazoles</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>1614-12-6</RegistryNumber>
<NameOfSubstance UI="C033020">1-aminobenzotriazole</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>34450-18-5</RegistryNumber>
<NameOfSubstance UI="C047008">17-octadecynoic acid</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>9035-51-2</RegistryNumber>
<NameOfSubstance UI="D003577">Cytochrome P-450 Enzyme System</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>QA22Z3NGLU</RegistryNumber>
<NameOfSubstance UI="C006983">4-chlorobiphenyl</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001713" MajorTopicYN="N">Biphenyl Compounds</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065607" MajorTopicYN="Y">Cytochrome P-450 Enzyme Inhibitors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003577" MajorTopicYN="N">Cytochrome P-450 Enzyme System</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004785" MajorTopicYN="N">Environmental Pollutants</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004791" MajorTopicYN="N">Enzyme Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005231" MajorTopicYN="N">Fatty Acids, Unsaturated</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014230" MajorTopicYN="N">Triazoles</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year>
<Month>1</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2013</Year>
<Month>1</Month>
<Day>17</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2014</Year>
<Month>4</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23320482</ArticleId>
<ArticleId IdType="doi">10.1021/es304298m</ArticleId>
<ArticleId IdType="pmc">PMC3652898</ArticleId>
<ArticleId IdType="mid">NIHMS438317</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Chemosphere. 2010 Sep;81(4):523-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20708213</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Res Toxicol. 2008 Jan;21(1):70-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18052394</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Sci Technol. 2010 May 15;44(10):3901-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20402517</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Cent J. 2011 Dec 20;5:87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22185578</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Sci Technol. 2013 Jan 2;47(1):557-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23215248</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Xenobiotica. 1989 Nov;19(11):1307-18</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2515663</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 1998 Mar;284(3):966-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9495856</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chemosphere. 2001 Dec;45(8):1119-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11695625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2006 May 26;344(1):129-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16616008</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Health Perspect. 1994 May;102(5):464-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8593850</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Res Toxicol. 2008 Oct;21(10):1997-2004</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18763812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Total Environ. 2004 Sep 20;331(1-3):125-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15325145</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chemosphere. 2009 Feb;74(7):950-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19054541</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Sci Technol. 2006 Jun 15;40(12):3696-703</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16830529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharmacol Exp Ther. 1994 Jan;268(1):474-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8301590</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Rev Toxicol. 1994;24(2):87-149</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8037844</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Metab Dispos. 2009 Jan;37(1):10-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18936109</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 1974 Aug 16;185(4151):573-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4841570</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Plant Physiol. 1998 May;117(1):123-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9576781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aquat Toxicol. 2006 Jun 15;78(2):176-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16621064</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Metab Dispos. 2002 Oct;30(10):1059-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12228180</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Microbiol. 2004 Aug;6(8):842-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15250886</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 1990 Apr 16;168(1):206-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2328000</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Health Perspect. 2007 Jan;115(1):20-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17366814</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Res Toxicol. 2012 Dec 17;25(12):2796-804</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23137097</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Metab Dispos. 2006 Dec;34(12):1985-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16997912</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Metab Dispos. 2011 Sep;39(9):1674-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21677062</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chemosphere. 1996 Feb;32(3):517-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8907228</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Res Toxicol. 1995 Jan-Feb;8(1):92-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7703372</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Pharmacol. 1988 Jul 1;37(13):2515-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3390214</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Fundam Appl Toxicol. 1994 Apr;22(3):369-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8050632</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Metab Dispos. 2003 May;31(5):631-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12695352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Biochem Biophys. 1995 Mar 10;317(2):464-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7893164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Biochem Biophys. 2003 Jan 1;409(1):59-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12464245</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cardiovasc Pharmacol. 1997 Jun;29(6):827-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9234666</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Environ Monit. 2004 Sep;6(9):758-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15346180</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Iowa</li>
</region>
<settlement><li>Iowa City</li>
</settlement>
<orgName><li>Université de l'Iowa</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Lehmler, Hans Joachim" sort="Lehmler, Hans Joachim" uniqKey="Lehmler H" first="Hans-Joachim" last="Lehmler">Hans-Joachim Lehmler</name>
<name sortKey="Schnoor, Jerald L" sort="Schnoor, Jerald L" uniqKey="Schnoor J" first="Jerald L" last="Schnoor">Jerald L. Schnoor</name>
</noCountry>
<country name="États-Unis"><region name="Iowa"><name sortKey="Zhai, Guangshu" sort="Zhai, Guangshu" uniqKey="Zhai G" first="Guangshu" last="Zhai">Guangshu Zhai</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PoplarV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002627 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002627 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    PoplarV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:23320482
   |texte=   Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23320482" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a PoplarV1

This area was generated with Dilib version V0.6.37.
Data generation: Wed Nov 18 12:07:19 2020. Site generation: Wed Nov 18 12:16:31 2020

	Serveur d'exploration sur le peuplier
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le peuplier

Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.

Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki